Diatom-derived oxylipins induce cell death in sea urchin embryos activating caspase-8 and caspase 3/7

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Diatom-derived oxylipins induce cell death in sea urchin embryos activating caspase-8 and caspase 3/7.

Diatoms are an important class of unicellular algae that produce bioactive secondary metabolites with cytotoxic activity collectively termed oxylipins, including polyunsaturated aldehydes (PUAs), hydroxyacids (HEPEs), oxo-acids and epoxyalcohols. Previous results showed that at higher concentrations, the PUA decadienal induced apoptosis on copepods and sea urchin embryos via caspase-3 activatio...

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A marine diatom-derived aldehyde induces apoptosis in copepod and sea urchin embryos.

The diatom-derived aldehyde 2-trans-4-trans-decadienal (DD) was tested as an apoptogenic inducer in both copepod and sea urchin embryos, using terminal-deoxynucleotidyl-transferase-mediated dUTP nick-end labelling (TUNEL), DNA fragmentation profiling (laddering) and an assay for caspase-3 activity. DD induced TUNEL positivity and DNA laddering, but not caspase-like activation, in copepod embryo...

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ژورنال

عنوان ژورنال: Aquatic Toxicology

سال: 2016

ISSN: 0166-445X

DOI: 10.1016/j.aquatox.2016.04.012